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Oral paracetamol acetaminophen for cancer pain. Non-opioid drugs are commonly used to treat mild to moderate cancer pain , and are recommended for this purpose in the WHO cancer pain treatment ladder, either alone or in combination with opioids.
A previous Cochrane review that examined the evidence for nonsteroidal anti-inflammatory drugs NSAIDs or paracetamol, alone or combined with opioids, for cancer pain was withdrawn in because it was out of date; the date of the last search was To assess the efficacy of oral paracetamol acetaminophen for cancer pain in adults and children, and the adverse events reported during its use in clinical trials.
We included randomised, double-blind, studies of five days' duration or longer, comparing paracetamol alone with placebo, or paracetamol in combination with an opioid compared with the same dose of the opioid alone, for cancer pain of any intensity. Single-blind and open studies were also eligible for inclusion. The minimum study size was 25 participants per treatment arm at the initial randomisation.
Two review authors independently searched for studies, extracted efficacy and adverse event data, and examined issues of study quality and potential bias. We did not carry out any pooled analyses. Three studies in adults satisfied the inclusion criteria, lasting up to one week; participants were randomised initially, and 95 completed treatment.
We found no studies in children. One study was parallel-group, and. Oral choline supplementation for postoperative pain. PubMed Central. Sidhu, N. Background Activation of nicotinic receptors with nicotine has been shown to reduce post-surgical pain in clinical and preclinical studies. It is anti-nociceptive in animal studies. We conducted a double-blind randomized trial of oral choline supplementation with lecithin to aid in the treatment of pain after gynaecological surgery.
Methods Sixty women having open gynaecological surgery were randomly assigned to receive 20 g of lecithin before surgery or placebo. Plasma choline concentration and tumour necrosis factor TNF were measured. Pain report was the primary outcome measure. Results We achieved a small but statistically significant increase in choline after surgery with oral supplementation. Plasma TNF was not decreased and pain report was not different between groups at rest or with movement.
There were no adverse effects of treatment. Conclusions Oral supplementation with lecithin during the perioperative period resulted in very slow absorption and thus only a small increase in plasma choline was achieved. This concentration was inadequate to reduce TNF as has been shown in other studies.
The absence of an anti-inflammatory effect was likely related to our failure to demonstrate efficacy in pain reduction. Oral Flurbiprofen Spray for Posttonsillectomy Pain.
Tonsillectomy is still one of the most common surgical procedures, but there exists no standard guideline for pain management after tonsillectomy.
Our aim is to determine whether oral spray of flurbiprofen reduces pain and has an influence on other morbid outcomes following tonsillectomy. Prospective, double-blind, randomized, placebo controlled. This study was performed on 84 patients 45 in flurbiprofen group, 39 in placebo group who underwent tonsillectomy. The patients were randomly chosen, and each used oral spray of flurbiprofen 3 times daily or placebo solution at the same regimen. Efficacy was assessed by changes in Numeric Pain Rating Scale.
Data were collected at postoperative days 1, 3, 5, and 7 for pain , bleeding, and healing. Data for Mallampati scores were also collected.
There were no significant difference between groups with respect to the demographic data. Healing and side effects were not significantly different between the groups. In this study, topical use of flurbiprofen may reduce posttonsillectomy pain without any evidence of additional complications.
Oral Gabapentin for Photorefractive Keratectomy Pain. Topical and oral. Oral contraceptives for pain associated with endometriosis. Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The combined oral contraceptive pill COCP is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited.
To determine the effectiveness, safety and cost-effectiveness of oral contraceptive preparations in the treatment of painful symptoms ascribed to the diagnosis of laparoscopically proven endometriosis.
We also handsearched reference lists of relevant trials and systematic reviews retrieved by the search. We included randomised controlled trials RCT of the use of COCPs in the treatment of women of reproductive age with symptoms ascribed to the diagnosis of endometriosis that had been made visually at a surgical procedure. Two review authors independently assessed study quality and extracted data. One review author was an expert in the content matter. We contacted study authors for additional information.
The primary outcome was self-reported pain dysmenorrhoea at the end of treatment. Five trials women met the inclusion criteria. Only three trials women provided data that were suitable for analysis. These studies were at high risk of bias. For GRADE outcomes self-reported pain dysmenorrhoea at the end of treatment , the quality of the evidence very low. Evidence was downgraded for imprecision as it was based on a single, small trial and.
Psychological factors in oral mucosal and orofacial pain conditions. The psychological aspects of chronic pain conditions represent a key component of the pain experience, and orofacial pain conditions are not an exception. In this review, we highlight how psychological factors affect some common oral mucosal and orofacial pain conditions namely, oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and temporomandibular disorders with emphasis on the significance of supplementing classical biomedical treatment modalities with appropriate psychological counseling to improve treatment outcomes in targeted patients.
A literature search restricted to reports with highest relevance to the selected mucosal and orofacial pain conditions was carried out to retrieve data. Single dose oral aspirin for acute postoperative pain in adults.
This review is an update of a previously published review in the Cochrane Database of Systematic Reviews on 'Single dose oral aspirin for acute pain '.
Aspirin has been known for many years to be an effective analgesic for many different pain conditions. Although its use as an analgesic is now limited in developed countries, it is widely available, inexpensive, and remains commonly used throughout the world. To assess the analgesic efficacy and associated adverse events of single dose oral aspirin in acute postoperative pain. Single oral dose, randomised, double-blind, placebo-controlled trials of aspirin for relief of established moderate to severe postoperative pain in adults.
We assessed studies for methodological quality and two review authors extracted the data independently. We sought numbers of participants using rescue medication over specified time periods, and time to use of rescue medication, as additional measures of efficacy. We collected information on adverse events and withdrawals.
There was only one new study. Studies were overwhelmingly of adequate or good. Oral ketamine for sickle cell crisis pain refractory to opioids. There is literature demonstrating that the N-methyl-d-aspartate NMDA receptor antagonist ketamine has analgesic properties that can be used as an adjuvant to opiates for pain relief in multiple various conditions and pain states.
However, there is a lack of published information on ketamine used in persons with sickle cell disease in acute pain crises. The Virginia Commonwealth University Palliative Care team was consulted on a year-old African American female with sickle cell thalassemia in severe acute pain crisis overlying chronic pain related to her disease. Pain control was unable to be achieved with escalating doses of opiates and other adjuvant medications.
The patient responded well to an intravenous test dose of ketamine and was subsequently placed on an oral regimen of ketamine in addition to opiates. In the hour period following ketamine initiation, the patient's pain was able to be controlled on decreased amounts of opiates. She was eventually transitioned to an oral opiate and ketamine regimen, which allowed her to be discharged home with pain levels close to her baseline and the ability to function and perform all activities of daily living.
Oral hyaluronan relieves knee pain : a review. Hyaluronan HA is a component that is particularly abundant in the synovial fluid. Randomized, double-blinded, placebo-controlled trials carried out between and have proven the effectiveness of HA for the treatment of symptoms associated with synovitis, and particularly, knee pain , relief of synovial effusion or inflammation, and improvement of muscular knee strength.
The mechanism by which HA exerts its effects in the living body, specifically receptor binding in the intestinal epithelia, has gradually been clarified. This review examines the effects of HA upon knee pain as assessed in clinical trials, as well as the mechanism of these effects and the safety of HA. Aboriginal oral traditions of Australian impact craters. In this paper we explore Aboriginal oral traditions that relate to Australian meteorite craters. Using the literature, first-hand ethnographic records and field trip data, we identify oral traditions and artworks associated with four impact sites: Gosses Bluff, Henbury, Liverpool and Wolfe Creek.
Oral traditions describe impact origins for Gosses Bluff, Henbury and Wolfe Creek Craters, and non- impact origins for Liverpool Crater, with Henbury and Wolfe Creek stories having both impact and non- impact origins. Three impact sites that are believed to have been formed during human habitation of Australia -- Dalgaranga, Veevers, and Boxhole -- do not have associated oral traditions that are reported in the literature. Dental infections, frequent in the general population, are a common cause of inflammation with systemic impact , and are the most common cause of orofacial pain.
Temporomandibular disorders are also frequent in the elderly and represent an important cause of secondary headache. We report a case of a year-old woman with AD and chronic facial pain who had a significant improvement in functional activities as well as in cognition and depressive symptoms after successful treatment of her facial pain.
Patients with AD have higher compromise of oral health with infections and teeth loss. The investigation of orofacial pain should be performed in patients with AD, because of the associations reviewed and given the potential for improvement as highlighted by this case. Dental pain among 10—15 year old children attending oral health promoting schools: A cross-sectional study. Introduction: Dental pain is a major public health problem and one of the consequences of oral diseases which requires significant adjustments in life management leading to decreased quality of life.
Objective: To assess prevalence of dental pain and its impact on daily life and to explore its relationship with oral health behavior and clinical oral status among year old school children attending oral health promoting schools. Method: This cross sectional study was conducted in 6 schools serving low -middle socio economic strata in Bangalore, India. A total of children were surveyed for history of dental pain during past 3 month.
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