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Dan Performer Mei Lanfang. Medium energy ion scattering MEIS. This report gives an overview about the technique and experimental study of medium energy ion scattering MEIS as a quantitative technique to determine and analyse the composition and geometrical structure of crystalline surfaces and near surface-layers by measuring the energy and yield of the backscattered ions. The use of a lower energy range of 50 to keV accelerated ions impinging onto the target surface and the application of a high-resolution electrostatic energy analyser ESA makes medium energy ion scattering spectroscopy into a high depth resolution and surface-sensitive version of RBS with less resulting damage effects.
This report details the first steps of research in that field of measurement technology using medium energetic backscattered ions detected by means of a semiconductor radiation detector instead of an ESA. The study of medium energy ion scattering MEIS has been performed using the 40 keV industrial ion implanter established at GNS Sciences remodelled with supplementary high voltage insulation for the ion source in order to apply voltages up to 45 kV, extra apertures installed in the beamline and sample chamber in order to set the beam diameter accurately, and a semiconductor radiation detector.
For measurement purposes a beam of positive charged helium ions accelerated to an energy of about 80 keV has been used impinging onto target surfaces of lead implanted into silicon PbSi , scandium implanted into aluminium ScAl , aluminium foil Al and glassy carbon C. First results show that it is possible to use the upgraded industrial implanter for medium energy ion scattering. The 5 nA ion beam hit the samples under 2 x 10 -8 mbar. The results using the surface barrier detector show scattering events from the samples.
Cooling of the detector to liquid nitrogen temperatures reduced the electronic noise in the backscattering spectrum close to zero. The androgen receptor AR plays critical roles in human prostate carcinoma progression and transformation. However, the activation of AR is regulated by co-regulators. MEIS 1 protein, the homeodomain transcription factor, exhibited a decreased level in poor-prognosis prostate tumors.
Structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints are investigated. Appell equations and differential equations of motion for holonomic mechanic systems with unilateral constraints are established. The definition and the criterion of Mei symmetry for Appell equations in holonomic systems with unilateral constraints under the infinitesimal transformations of groups are also given.
The expressions of the structural equation and Mei conserved quantity of Mei symmetry for Appell equations in holonomic systems with unilateral constraints expressed by Appell functions are obtained. An example is given to illustrate the application of the results.
Wetzels, W. This report contains the outcomes of an evaluation study of the Market introduction Energy Innovations MEI subsidy scheme. This scheme is targeted to the horticultural sector and aims to stimulate and accelerate the early market introduction of innovative energy systems in greenhouses.
The subsidy scheme was initiated in and has provided subsidies twice a year since then. Based on project and data analysis, stakeholder interviews and a workshop, the evaluation concludes that the MEI scheme has made a positive contribution to the innovation process in the sector, but that the scheme could have been implemented more efficiently [Dutch] De regeling Marktintroductie energie-innovaties MEI is in ingesteld door het toenmalige Ministerie van Landbouw, Natuur en Voedselkwaliteit.
Het doel van de MEI -regeling is het stimuleren en versnellen van de vroege marktintroductie van innovatieve energiesystemen in de glastuinbouw. De centrale conclusie is dat de regeling een positieve bijdrage heeft geleverd aan het innovatieproces in de glastuinbouwsector. The Shugoshin Sgo protein family helps to ensure proper chromosome segregation by protecting cohesion at the centromere by preventing cleavage of the cohesin complex.
Some Sgo proteins also influence other aspects of kinetochore-microtubule attachments. Although many Sgo members require Aurora B kinase to localize to the centromere, factors controlling delocalization are poorly understood and diverse.
Moreover, it is not clear how Sgo function is inactivated and whether this is distinct from delocalization. We investigated these questions in Drosophila melanogaster, an organism with superb chromosome cytology to monitor Sgo localization and quantitative assays to test its function in sister-chromatid segregation in meiosis.
Previous research showed that in mitosis in cell culture, phosphorylation of the Drosophila Sgo, MEI-S , by Aurora B promotes centromere localization, whereas Polo phosphorylation promotes delocalization. These studies also suggested that MEI-S can be inactivated independently of delocalization, a conclusion supported here by localization and function studies in meiosis.
Phosphoresistant and phosphomimetic mutants for the Aurora B and Polo phosphorylation sites were examined for effects on MEI-S localization and chromosome segregation in meiosis.
Strikingly, MEI-S with a phosphomimetic mutation in the Aurora B phosphorylation site prematurely dissociates from the centromeres in meiosis I. Despite the absence of MEI-S on meiosis II centromeres in male meiosis, sister chromatids segregate normally, demonstrating that detectable levels of this Sgo are not essential for chromosome congression, kinetochore biorientation, or spindle assembly.
Specifically, expression of MEIS 2A was low in aggressive stage 4 neuroblastoma but high in spontaneously regressing stage 4S neuroblastoma. Moderate elevation of MEIS 2A expression reduced proliferation of MYCN -amplified human neuroblastoma cells, induced neuronal differentiation and impaired the ability of these cells to form tumors in mice.
Mechanistically, MEIS 2A uncoupled a negative feedback loop that restricts accumulation of cellular retinoic acid, an effective agent in neuroblastoma treatment. Overall, our results illuminate the basis for spontaneous regression in neuroblastoma and identify an MEIS 2A-specific signaling network as a potential therapeutic target in this common pediatric malignancy.
Significance: This study illuminates the basis for spontaneous regressions that can occur in a common pediatric tumor, with implications for the development of new treatment strategies.
Cancer Res; 78 8 ; The main purpose of this technical documentation is to clearly establish the key ideas and methods used during development of the MEI -model. This document introduces in this way the technical set-up of the model for application developers and administrators.
In describing how MEI version 2 works. This "Project Sheet" describes an on-going project that is being carried out by a group of educational researchers, computer science researchers and librarians from Universiti Sains Malaysia, Penang.
In this brief…. Lie- Mei symmetry and conserved quantities of the Rosenberg problem. The Rosenberg problem is a typical but not too complicated problem of nonholonomic mechanical systems. The Lie— Mei symmetry and the conserved quantities of the Rosenberg problem are studied. For the Rosenberg problem, the Lie and the Mei symmetries for the equation are obtained, the conserved quantities are deduced from them and then the definition and the criterion for the Lie— Mei symmetry of the Rosenberg problem are derived.
Finally, the Hojman conserved quantity and the Mei conserved quantity are deduced from the Lie— Mei symmetry. De novo MEIS 2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux. MEIS 2 aberrations are considered to be the cause of intellectual disability, cleft palate and cardiac septal defect, as MEIS 2 copy number variation is often observed with these phenotypes.
To our knowledge, only one nucleotide-level change-specifically, an in-frame MEIS 2 deletion-has so far been reported. Here, we report a female patient with a de novo nonsense mutation c. By reviewing this patient and previous patients with MEIS 2 point mutations, we found that feeding difficulty with gastro-esophageal reflux appears to be one of the core clinical features of MEIS 2 haploinsufficiency, in addition to intellectual disability, cleft palate and cardiac septal defect.
Directory of Open Access Journals Sweden. Full Text Available Meis 1 is recognized as an important transcriptional regulator in hematopoietic development and is strongly implicated in the pathogenesis of leukemia, both as a Hox transcription factor co-factor and independently. Despite the emerging recognition of Meis 1's importance in the context of both normal and leukemic hematopoiesis, there is not yet a full understanding of Meis 1's functions and the relevant pathways and genes mediating its functions.
Recently, several conditional mouse models for Meis 1 have been established. These models highlight a critical role for Meis 1 in adult mouse hematopoietic stem cells HSCs and implicate reactive oxygen species ROS as a mediator of Meis 1 function in this compartment.
There are, however, several reported differences between these studies in terms of downstream progenitor populations impacted and effectors of function. Findings obtained from these two inducible Meis 1 knockout models confirm and extend previous reports of the essential role of Meis 1 in adult HSC maintenance and expansion and provide new evidence that highlights key roles of Meis 1 in both megakaryopoiesis and erythropoiesis.
Gene expression analyses point to a number of candidate genes involved in Meis 1's role in hematopoiesis. Our data additionally support recent evidence of a role of Meis 1 in ROS regulation. Conformal invariance and conserved quantities of Appell systems under second-class Mei symmetry. In this paper we introduce the new concept of the conformal invariance and the conserved quantities for Appell systems under second-class Mei symmetry.
The one-parameter infinitesimal transformation group and infinitesimal transformation vector of generator are described in detail. The conformal factor in the determining equations under second-class Mei symmetry is found. The relationship between Appell system's conformal invariance and Mei symmetry are discussed.
And Appell system's conformal invariance under second-class Mei symmetry may lead to corresponding Hojman conserved quantities when the conformal invariance satisfies some conditions. Lastly, an example is provided to illustrate the application of the result. Hubungan panjang berat dan faktor kondisi ikan gabus Channa striata Bloch, yang dibesarkan di rawa lebak, Provinsi Sumatera Selatan. Hasil penelitian menunjukkan hubungan panjang berat tidak menunjukkan perbedaan nyata antara rawa Sekayu dan Mariana dengan nilai b di bawah nilai 3 yang berarti pertumbuhan ikan gabus tersebut allometrik negatif.
Ikan gabus yang dipelihara di rawa lebak Mariana menghasilkan faktor kondisi 0, lebih tinggi daripada di rawa lebak Sekayu 0,, yang menunjukkan bahwa kondisi lingkungan rawa lebak Mariana lebih mendukung untuk pertumbuhan ikan gabus. Meis 1: effects on motor phenotypes and the sensorimotor system in mice. RLS is a movement disorder leading to severe sleep reduction and has a substantial impact on the quality of life of patients. In genome-wide association studies, MEIS 1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation.
Therefore, haploinsufficiency of Meis 1 could be the system with the most potential for modeling RLS in animals. We used heterozygous Meis 1-knockout mice to study the effects of Meis 1 haploinsufficiency on mouse behavioral and neurological phenotypes, and to relate the findings to human RLS.
The mutant mice showed a pattern of circadian hyperactivity, which is compatible with human RLS. Moreover, we discovered a replicable prepulse inhibition PPI deficit in the Meis 1-deficient animals. In addition, these mice were hyposensitive to the PPI-reducing effect of the dopaminergic receptor agonist, highlighting a role of Meis 1 in the dopaminergic system.
Other reported phenotypes include enhanced social recognition at an older age that was not related to alterations in adult olfactory bulb neurogenesis previously shown to be implicated in this behavior. In conclusion, the Meis 1-deficient mice fulfill some of the hallmarks of an RLS animal model, and revealed the role of Meis 1 in sensorimotor gating and in the dopaminergic systems modulating it.
Assays were performed in primary cultures and established cell lines derived from embryos. An endonuclease preparation from M. The mutant mei , which is also deficient in meiotic recombination, removes nuclease-sensitive sites at control rates. In mei -9 cells DNA synthesis and possibly postreplication repair are weakly sensitive to caffeine.
Larvae which are hemizygous for either of the two mutants that define the mei -9 locus are hypersensitive to killing by the mutagens methyl methanesulfonate, nitrogen mustard and 2-acetylaminofluorene. Larvae hemizygous for the mei mutant are insensitive to each of these reagents. These data demonstrate that the mei -9 locus is active in DNA repair of somatic cells. Thus functions involved in meiotic recombination are also active in DNA repair in this higher eukaryote.
The results are consistent with the earlier suggestions that the mei -9 locus functions in the exchange events of meiosis. The mei mutation behaves differently in genetic tests and our data suggest its function may be restricted to meiosis. These studies demonstrate that currently recognized modes of DNA repair can be efficiently detected in primary cell cultures derived from Drosophila embryos.
Because Hox proteins have notoriously low binding specificity, they are believed to bind with cofactors, mainly homeodomain TFs Pbx and Meis , to select their specific targets. We mapped binding of Meis , Pbx, and Hoxa2 in the branchial arches, a series of segments in the developing vertebrate head.
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